PICOT is different from a standard, topically-based research question. It is a structured search strategy that is derived from a clinical scenario and provides a framework for asking well-worded questions. The purpose of PICO is to assist in identifying the best available evidence in order to improve healthcare outcomes. You as a clinician are translating this evidence to practice in order to assist with the decision-making process. Findings from your searches could ultimately lead to changes in a patient's treatment for a particular condition, an alteration of his or her lifestyle choices, or to a better quality of life. In gathering the best literature out there through this clinically-driven search strategy, your research can have real-life impact, and PICOT can help you get there!